P . T . Sharpe in Tooth Development : Co - ordination of Odontogenesis and Osteogenesis
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منابع مشابه
Expression of Wnt signalling pathway genes during tooth development
We have carried out comparative in situ hybridisation analysis of six Wnt genes Wnts-3, -4, -5a, -6, -7b, and 10b together with Wnt receptor MFz6 and receptor agonist/antagonists MFrzb1 and Mfrp2 during murine odontogenesis from the earliest formation of the epithelial thickening to the early bell stage. Expression of Wnt-4, Wnt-6, and one Wnt receptor MFz6 was observed in the facial, oral and ...
متن کاملTotal Evidence Versus Relevant
THEWISSEN, J. G. M., E. M. WILLIAMS, L. J. ROE, AND S. T. HUSSAIN. 2001. Skeletons of terrestrial cetaceans and the relationships of whales to artiodactyls. Nature 413:277–281. TUCKER, A. S., K. L. MATHEWS, AND P. T. SHARPE. 1998 Transformation of tooth type induced by inhibition of BMP signaling. Science 282:1136–1138. TUCKER, A. S., AND P. T. SHARPE. 1999. Molecular genetics of tooth morphoge...
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Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm, the oral epithelium and an underlying mesenchyme. During their early development, tooth germs exhibit many morphological and molecular similarities with other developing epithelial appendages, such as hair follicles, mammary and salivary glands, lungs, kidneys, etc. The developing mouse tooth g...
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Although features of the dentition figure prominently in discussions of early hominid phylogeny, remarkably little is known of the developmental basis of the variations in occlusal morphology and dental proportions that are observed among taxa. Recent experiments on tooth development in mice have identified some of the genes involved in dental patterning and the control of tooth specification. ...
متن کاملWnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development.
Interactions between the Wnt (wingless) and hedgehog signaling pathways were first described as playing a role in establishing boundaries between ectodermal cells in Drosophila segmentation. During the initiation of mammalian tooth development, boundaries that distinguish oral from dental ectoderm must be formed to correctly position the sites of tooth formation. We describe a reciprocal relati...
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